This will be the third time the clubs will meet in this competition, having met in 1956 and 2011 – which United have won both.

Manchester United have been hampered once again with injuries at the back with Jonny Evans, Diogo Dalot and Lisandro Martinez the only available defenders for Erik ten Hag.

However, new summer signing Joshua Zirkzee could feature from the start, due to Rasmus Højlund’s latest injury.

City stars Phil Foden, Kyle Walker, Rodri and John Stones have not featured in any of City’s pre-season matches and aren’t expected to start. City will also be missing Julian Alvarez, who is sealing a move to Atletico Madrid.

Predicted Lineups:

Manchester United: Andre Onana, Harry Amass, Lisandro Martinez, Jonny Evans, Diogo Dalot, Casemiro, Scott McTominay, Bruno Fernandes, Marcus Rashford, Joshua Zirkzee, Amad Diallo.

Manchester City: Stefan Ortega, Josko Gvardiol, Manuel Akanji, Ruben Dias, Rico Lewis, Mateo Kovacic, Kevin de Bruyne, Oscar Bobb, James McAtee, Jack Grealish, Erling Haaland.

Kick-off at Wembley Stadium is at 3pm.